The final boss of the game, from Map 30: Icon of Sin, utters a garbled message as you teleport into the room. If you play said message backwards it says, "To win the game, you must kill me, John Romero". Indeed, if a player activates the 'no clip' cheat and walks behind the wall on which the boss is held they'd find an object that looks like the head of John Romero, co-founder of ID Software and one of the main designers of Doom.
Contributed By: Ryan Harrison
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