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I use my 3DS fairly often...It is nice being able to play in bed before sleep. Truth be told, I use my portable systems more often than my other consoles at the moment because of this. I can sneak more gaming in this way. Playing on the tv or pc is more of a time commitment. I do prefer it in a way because I play on a projector, so everything is epic, but my handheld devices (3DS and GBA SP) get a lot of love too.
I second the recommendation for MH4U. It is glorious, and there are still supportive players online.
I also recommend Resident Evil Revelations, though you can play that on Wii U as well... And that's only the beginning. There are tonnes of great games!
I won't say my 2DS is my main...but I do enjoy it a lot. I guess it depends but while I've been focused on one Switch game, the 2DS has took more time for the past month than any other console/handheld. It's such an amazing handheld and I regret not jumping in sooner.
I have a Mario Maker 2DS that I've been debating making my DS player and just play DS games on it. Of course, I need to get rid of some of this 3DS game backlog...which will take some time.