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the numbers on the mechanics are still too different. any champion can one-shot all early zeg units with an auto attack, and any AP character with an AOE will melt any army that tries to overhwelm them, which would be the only thing that works.
Even if the range numbers were tweaked to be reasonable, only broodlords could make even a dent, and they are so late game that you would never see them.
Only way it could work mechanically without major rebalancing everywhere would be if it was your team of lol champions against a single player campaign zerg base, that takes up most of the map. And even then anyone with a spammable aoe would destroy. Soraka would be unstoppable.
I could argue about how the world of league of legends wouldn't be able to survive a zerg invasion in lore until the cows came home, but in gameplay, statistics unchanged, it won't happen. It could barely even be possible under most ideal conditions, that including the entire league team being only single-target damage dealers who never reach a level higher than 6, against a pre-built zerg base.
The guy who thinks Karma is a viable champion. Hero's aren't made. They're cornered.
Considering that the beefiest unit zerg has only has 5 armor fully upgraded and like 500 hp, I think the champs would win.. but champs can't attack flying units... and and an army of banelings would destroy!
"A cornered fox is more dangerous than a jackal!" -Grayfox XBL/PSN : GrayFox312k