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1. does not often vary characters , so you end up getting stuck or not being able to access something if you don't have a certain character type. 2. you often get multiple characters that are similar example: Goon and goon. 3. ... actually thats about it.
Yeah, there have been a lot of times I needed a character that could pass through cold areas or the green goo stuff and it wouldn't give me either.
I don't know exactly when, but at some point, you can unlock a character named Azreal (or something like that) and he is great. He can pass through the green goo, he has super strength, he can double jump and a few other things. For free play, if you pick him, then you shouldn't lack of any character with a specific ability other than possibly missing out on a cold-based character.