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I've played through ME many times, but just now was having an issue with manual overrides while playing through it with backwards compatibility on Xbox one.
Couldn't figure out for the life of me what was happening it would only register properly if I would hit it the millisecond it highlighted a button. I tried rebooting in a number of things expecting it to be a glitch searched and found an old thread here that didn't resolve it. But then I remembered to double check the video game mode on my TV and it had somehow switched to off. I turned it on and immediately had no issues with manual overrides.
Just something to keep in mind that I figured might save someone headaches down the road