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f*** him. At least with when he starts flying around it gets much easier because you can move away from him and his attacks but for the first half when you only have half a screen to dodge, his attacks are so fast and your movement is so limited they become the hardest attacks to dodge in the game. Unless you have extreme damage to kill him in seconds then I'd rather face Hush, at least all of his attacks are slow and give you time to think in response.
I'm looking for Animal Crossing Friends, just got the game. PM me! FC: 1864-9707-5038
I find Satan to be way harder, one of the hardest bosses in the game. Forcing you to fight the Fallen first, the extremely fast spreadshots, and the half-second reaction time brimstone lasers. Then in Phase 2 he likes to cover up the kamikaze leeches with his legs.
Isaac is one of the tamer final bosses, and my personal favorite boss in the game.