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If you can win with the Keeper then the Lost should be no problem. If you have that much trouble then either just keep doing runs until it's natural or just reset until either a dead cat curse room or great item in an item room. If you're going for Boss Rush then aim for Gnawed Leaf for sure because it's crazy, even moreso now that the bosses are random and can't be predicted anymore, glad I cheesed it with GL before AB.