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Health powerups are largely useless because it regenerates over time anyway, and your shield is really what soaks up most of the damage. The game is pretty much like every other post-halo FPS game where you either take a lot of fire in a battle and die, or you don't and you live.
There are no health kits like in the first game, provably why packspace is only 27. But, I do hope Gearbox implement a health kit drop and more packspace. If that happens make a specific button to use the healthkits or just have you go into the inventory to use them.
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