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Game seems designed so that youve got to use all 8 characters.
Would have massively extended replayability if you could only use one, or more, but not all of the starting chars per game.
With that being said, im only playing through once.
If you play the game once with all 8 characters or 8 times with 1 character, it would all balance out anyway. I wouldn't even call playing a game with a different character and story from the beginning a "replay", more continuing to play.