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I personally don't think they're worth the money. By the time you hit Level 100+, you should have most of the things you want, either directly from level-up boxes or from coins. Loot boxes are only mildly enjoyable for me now since there aren't many things I want that I don't already have. I'm sitting on about 3000 coins, because I don't want anything else badly enough to spend my coins, and also because I want to have something to look forward to in my future loot boxes.
EDIT: To be fair though, a handful of the skins I prefer are the epic (250) skins rather than the legendary (1000) skins, so I guess the things I want are cheaper overall than if I only liked legendary skins.
Spent 40 bucks on boxes, no regrets. You just have to decide for yourself it this is worth it, since you do get a lootbox every time you level up, all what spending money does, is progress faster through the skins.