Vanguard with Charge/Nova/Annilation

Would a set up like that with a shotgun be a good set up? Is it better to change out Nova for a biotic detonator since it only primes or does it not make too much of a difference since you can hit the enemy with charge again if need be. I kind of want to keep annihilation/charge. Alternatively I was thinking of going energy drain/cryo beam/charge

I tried this combo, and found that unfortunately its use is hampered by the fact that Nova is no longer a detonator. I recommend replacing either Nova or Annihilation with something like Throw so you can detonate enemies that are primed by Annihilation/Nova.

Annihilation unfortunately doesn't prime Charge. You're better off with a priming Shockwave and Nova. Charge->Nova(primes)->Shockwave(detonates and primes for a follow up Charge).

Annihilation is great with Throw and Shockwave and/or Lance.

So right now I’m still running charge with bastion and shield powered Nova with annihilation. Was thinking of changing Nova to the seismic nova version. I know they don’t detonate each other but using nova +melee + charge + aerial melee is just too much fun. I’m liking the biotic amplifier. Haven’t tried the Omni blade yet or the hammer